Appendix
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Endocrinology

Biochemistry, Polyol Or Sorbitol Pathways

The sorbitol or polyol pathway is a two-step metabolic pathway that converts glucose into fructose. This pathway is thought to play a prominent role in explaining the pathogenesis of complications in patients with end-stage diabetes. In light of this, this activity presents the biochemistry behind this pathway, summarizes the individual reactions and their importance, reviews the prevailing hypothesis explaining why this pathway plays a role in end-stage diabetes, and explores the clinical signi

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  • Without early intervention and adequate glycemic control, the complications formed from the polyol pathway can become permanent and significantly decrease quality of life.
  • Nuclear magnetic resonance was utilized to examine diabetic cataractogenesis
  • adequate glycemic control
  • GLP-1 agonists and SGLT-2 inhibitors are efficacious in reducing renal oxidative stress and their effects on glycemic control.
GLP-1 agonists
Not specified in source
Adult
Not specified in source
Renal
Not specified in source
Duration
Not specified in source
SGLT-2 inhibitors
Not specified in source
Adult
Not specified in source
Renal
Not specified in source
Duration
Not specified in source
  • Aldolase reductase inhibitors have been extensively researched to examine whether they can be effective treatments.
  • Adverse effects of these drugs include hypersensitivity reactions.
  • The polyol pathway has also been credited as an explanation of complications in diabetic patients, specifically in the kidney, retina, and nerves.
  • Research has shown that in diabetic patients, the polyol pathway decreases glutathione and NADPH levels due to the low activity of glutathione reductase.
  • review
    Biochemistry, Polyol Or Sorbitol Pathways. StatPearls [Internet] — Kishan K. Srikanth, Josephine A. Orrick — StatPearls Publishing, 2022

Decision support only. Verify against local protocols and current labeling. Source: www.ncbi.nlm.nih.gov